Kémia | Biokémia » Enzimek gátlása

$=(1=,05($.&,Ï*È72/+$7Ï6È$ )RQWRVViJ )L]LROyJLiVV]DEiOR]iV .XWDWiV PĦN|GpVPHFKDQL]PXVD 7R[LNROyJLD *yJ WiV 5HYHU]LELOLVJiWOiV , ,QKLELWRU UHYHU]LELOLVHQN|WĘGLN D]HQ]LPKH]FRHQ]LPKH] ,UUHYHU]LELOLVJiWOiV  NRYDOHQVN|WpV  ROGDOOiQF± NRQIRUPiFLyEHIROiVROiV  NDWDOtWLNXVKHODPLQRVDYDLYDOUHDNFLy -HOHQWiUJDOiV5(9(5=,%,/,6*È7/È62. .203(7,7Ë9*È7/È6 • HILQtFLy$]LQKLEtWRU UHYHU]LELOLVHQN|WĘGLND] DNWtYKHOKH] • $]LQKLEtWRUMHOHQOpWpEHQ DV]XEV]WUiWQHP N|WĘGLN • $JiWOiVD>6@Q|YHOpVpYHO FV|NNHQWKHWĘ >(@>,@ .L >(,@ &22 &22 &+ &+ &+  Acceptor &22 &22 &22 &+ &+ &22 &+  AcceptorH2 &22  &+ &22  Acceptor *È72/7 5($.&,Ï • HILQtFLy$]LQKLEtWRU UHYHU]LELOLVHQN|WĘGLND] DNWtYKHOKH] • $]LQKLEtWRUMHOHQOpWpEHQ DV]XEV]WUiWQHP N|WĘGLN • $JiWOiVD>6@Q|YHOpVpYHO FV|NNHQWKHWĘ 9 9

Inhibitor nélkül >,QKLELWRU@ >,QKLELWRU@ YPD[ >,QKLELWRU@ KM .0 ¶ .0¶¶ >,QKLELWRU@ >6@ .0 0¶¶ Inhibitor nélkül >6@ 9 9 Inhibitor nélkül >,QKLELWRU@ >,QKLELWRU@ YPD[ >,QKLELWRU@ KM .0 ¶ .0¶¶ >,@ .0¶ 0 BB .L >,QKLELWRU@ >6@ .0 0¶¶ .0 0¶ Inhibitor nélkül >6@ >,@ BB .L 1(0.203(7,7Ë9*È7/È6 • HILQtFLy$]LQKLEtWRU UHYHU]LELOLVHQN|WĘGLN • $](,NRPSOH[QHPD V]XEV]WUiWN|WĘKHOHQ M|QOpWUH • 1LQFV|VV]HIJJpVD JiWOiVPpUWpNHpVD>6@ N|]|WW • $JiWOiVPpUWpNpWD]>,@ KDWiUR]]DPHJ P P 1(0.203(7,7Ë9*È7/È6 (, (, (6, (6, Mindkét komplex inaktív 1(0.203(7,7Ë9*È7/È6 • • • • HILQtFLy$]LQKLEtWRUUHYHU]LELOLVHQ N|WĘGLN $](,NRPSOH[QHPDV]XEV]WUiW N|WĘKHOHQM|QOpWUH 1LQFV|VV]HIJJpVDJiWOiVPpUWpNHpV D>6@N|]|WW $JiWOiVPpUWpNpWD]>,@KDWiUR]]D PHJ 9 P P

1(0.203(7,7Ë9*È7/È6 9 ,QKLELWRUQpONO 9PD[ ,QKLELWRU ,QKLELWRU ,QKLELWRUQpONO ,QKLELWRU 9PD[¶ ,QKLELWRU YPD[ 9PD[¶¶ .0 >6@ .0 >6@ 9 9 ,QKLELWRUQpONO 9PD[ ,QKLELWRU ,QKLELWRU ,QKLELWRUQpONO ,QKLELWRU 9PD[¶ ,QKLELWRU YPD[ 9PD[¶¶ .0 .0 >6@ YPD[ YPD[¶ >,@NL >6@ YPD[¶ YPD[ >,@NL +D>,@ .LDNNRUYPD[¶ YPD[ 81.203(7,7Ë9*È7/È6 • • $]LQKLELWRUD](6 NRPSOH[KH]N|WĘGLN $>6@Q|YHOpVpYHODJiWOiV QHPFV|NNHQWKHWĘ (6, (6, >(6,@ ., BBBBBBBB >(6@>,@ ,QDNWtYNRPSOH[ 9 Inhibitor 2 YPD[ .0 ,QKLELWRU Inhibitor nélkül >6@